Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve.

@article{Pernet2013LongdistanceAR,
  title={Long-distance axonal regeneration induced by CNTF gene transfer is impaired by axonal misguidance in the injured adult optic nerve.},
  author={Vincent Pernet and Sandrine Joly and Deniz Dalkara and No{\'e}mie Jordi and Olivia Schwarz and Franziska Christ and David V. Schaffer and John G Flannery and Martin E. Schwab},
  journal={Neurobiology of disease},
  year={2013},
  volume={51},
  pages={202-13}
}
The optic nerve crush injury is a well-accepted model to study the mechanisms of axonal regeneration after trauma in the CNS. The infection of retinal ganglion cells (RGCs) with an adeno-associated virus serotype 2 - ciliary neurotrophic factor (AAV2.CNTF) was previously shown to stimulate axonal regeneration. However, the transfection of axotomized neurons themselves may not be optimal to promote full axonal regeneration in the visual system. Here, we show that the release of CNTF by glial… CONTINUE READING
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