Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis.

@article{Jensen1996LongCA,
  title={Long crocidolite asbestos fibers cause polyploidy by sterically blocking cytokinesis.},
  author={C. Gregory Jensen and L. C. W. Jensen and C L Rieder and Richard W. Cole and Jeffrey G. Ault},
  journal={Carcinogenesis},
  year={1996},
  volume={17 9},
  pages={2013-21}
}
Asbestos has been described as a physical carcinogen in that its carcinogenic effects appear to be related primarily to fiber dimensions. It has been hypothesized that long asbestos fibers may interfere with chromosome distribution during cell division, causing genomic changes that lead to cell transformation and neoplastic progression. Using high-resolution time-lapse light microscopy and serial-section electron microscopy, we have followed individual crocidolite asbestos fibers through the… CONTINUE READING