Long circulating self-assembled nanoparticles from cholesterol-containing brush-like block copolymers for improved drug delivery to tumors.

@article{Tran2014LongCS,
  title={Long circulating self-assembled nanoparticles from cholesterol-containing brush-like block copolymers for improved drug delivery to tumors.},
  author={Tran Tran and Chi Thanh Nguyen and Laura Gonz{\'a}lez-Fajardo and Derek Hargrove and Donghui Song and Prashant S. Deshmukh and Lalit Mahajan and Dennis Ndaya and Laijun Lai and Rajeswari M. Kasi and Xiuling Lu},
  journal={Biomacromolecules},
  year={2014},
  volume={15 11},
  pages={
          4363-75
        }
}
Amphiphilic brush-like block copolymers composed of polynorbonene-cholesterol/poly(ethylene glycol) (P(NBCh9-b-NBPEG)) self-assembled to form a long circulating nanostructure capable of encapsulating the anticancer drug doxorubicin (DOX) with high drug loading (22.1% w/w). The release of DOX from the DOX-loaded P(NBCh9-b-NBPEG) nanoparticles (DOX-NPs) was steady at less than 2% per day in PBS. DOX-NPs were effectively internalized by human cervical cancer cells (HeLa) and showed dose-dependent… CONTINUE READING
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