Long and short isoforms of Neurospora clock protein FRQ support temperature-compensated circadian rhythms.

@article{Diernfellner2007LongAS,
  title={Long and short isoforms of Neurospora clock protein FRQ support temperature-compensated circadian rhythms.},
  author={Axel C. R. Diernfellner and Hildur V. Colot and Orfeas Dintsis and Jennifer J. Loros and Jay C. Dunlap and Michael Brunner},
  journal={FEBS letters},
  year={2007},
  volume={581 30},
  pages={5759-64}
}
The large (l) and small (s) isoforms of FREQUENCY (FRQ) are elements of interconnected feedback loops of the Neurospora circadian clock. The expression ratio of l-FRQ vs. s-FRQ is regulated by thermosensitive splicing of an intron containing the initiation codon for l-FRQ. We show that this splicing is dependent on light and temperature and displays a circadian rhythm. Strains expressing only l-FRQ or s-FRQ support short and long temperature-compensated circadian rhythms, respectively. The… CONTINUE READING

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