Long-acting oily chloramphenicol for meningococcal meningitis

  title={Long-acting oily chloramphenicol for meningococcal meningitis},
  author={Rosamund F. Lewis and F Dorlencourt and Jacques Pinel},
  journal={The Lancet},
A glimpse of antimicrobial resistance gene diversity in kefir and yoghurt
Results presented suggest that starting culture strains of fermented food should be monitored and selected to decrease the ARG amount intake by nutrition, and support that theory during the fermentation process the food ARG content can grow by the bacteria multiplication.
Practical considerations when initiating insulin
The authors will discuss when insulin should be started, selection of insulin, common barriers and potential strategies for the initiation of insulin in type 2 diabetes.
Formulation optimization of palm kernel oil esters nanoemulsion-loaded with chloramphenicol suitable for meningitis treatment.
The results showed that the optimized compositions have the potential to be used as a parenteral emulsion to cross blood-brain barrier (BBB) for meningitis treatment.
Emerging drugs for acute bacterial meningitis
The use of dexamethasone seems to be helpful under conditions of rapid etiological diagnosis and prompt management, and drugs that neutralize bacterial factors or host mechanisms involved in induction of inflammatory response are under development.
Incidence, seasonality, age distribution, and mortality of pneumococcal meningitis in Burkina Faso and Togo.
To better inform vaccine policy, continued and expanded surveillance of acute bacterial meningitis among persons of all ages in Burkina Faso and Togo in 2002-2006 is essential to document serotypes associated with pneumonia, changes in serotype distribution across time, and the impact of vaccine after vaccine introduction.
The diagnosis and management of acute bacterial meningitis in resource-poor settings
Improved access to affordable antibiotics will not overcome the problems of poor access to hospitals and the fatal consequences of delayed treatment, so the future rests with the provision of effective conjugate vaccines against S pneumoniae, Haemophilus influenzae, and Neisseria meningitides to children in the poorest regions of the world.
Epidemiological and molecular characteristics of a highly lethal pneumococcal meningitis epidemic in Burkina Faso.
  • S. Yaro, M. Lourd, +9 authors B. Gessner
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2006
Although a serotype 1 clone was commonly isolated, over half of the cases were caused by other serogroups and/or serotypes, and genetic diversification increased over a relatively short period.


Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis
It is suggested that long-acting chloramphenicol is a useful first-line presumptive treatment for BM in high-incidence countries.
A field trial of a single intramuscular injection of long-acting chloramphenicol in the treatment of meningococcal meningitis.
Results of this preliminary study show that a single dose injection of a long-acting chloramphenicol is of value in the management of epidemics of meningococcal meningitis in rural areas because patients can be treated locally and early in their village dispensaries, thereby minimizing the need to transport them to urban hospitals which are often distant and congested.
Single injection treatment of meningococcal meningitis. 2. Long-acting chloramphenicol.
Long-acting chloramphenicol is an effective form of treatment for meningococcal meningitis and is likely to prove of particular value in the management of epidemics in areas with limited medical resources.
Traitement minute de la méningite cérébro-spinale épidémique par injection intramusculaire unique de chloramphénicol (suspension huileuse)*
C'est ainsi qu'en Afrique sub-saharienne, dans les regions arides particulierement touchees par ces epidemies, la plupart des cas ne peuvent qu'etre traites sur place par des equipes sanitaires itinerantes.