Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma

@inproceedings{Kraft2017LongactingCA,
  title={Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma},
  author={John C. Kraft and Lisa A. McConnachie and Josefin Koehn and Loren M Kinman and Carol Collins and Danny D. Shen and Ann C Collier and Rodney J. Y. Ho},
  booktitle={AIDS},
  year={2017}
}
OBJECTIVE The aim of the present study was to determine whether a combination of anti-HIV drugs - tenofovir (TFV), lopinavir (LPV) and ritonavir (RTV) - in a lipid-stabilized nanosuspension (called TLC-ART101) could enhance and sustain intracellular drug levels and exposures in lymph node and blood cells above those in plasma. DESIGN Four macaques were given a single dose of TLC-ART101 subcutaneously. Drug concentrations in plasma and mononuclear cells of the blood (PBMCs) and lymph nodes… CONTINUE READING
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