Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis

@article{Pcoul1991LongactingCV,
  title={Long-acting chloramphenicol versus intravenous ampicillin for treatment of bacterial meningitis},
  author={Bernard P{\'e}coul and Francis Varaine and Mohamed Keita and G. Soga and Audrey Marie-Delphine Djibo and Georges Soula and Aziza Abdelaziz Abdou and J. Etienne and M. Rey},
  journal={The Lancet},
  year={1991},
  volume={338},
  pages={862-866}
}
In most developing countries, bacterial meningitis (BM) is associated with a high case-fatality rate. The search for a simple, convenient, and inexpensive antibiotic treatment remains a priority. In this study, a non-blinded, multicentre, randomised clinical trial of 528 cases of BM was done in two hospitals in Mali and Niger, between March, 1989, and May, 1990, to see whether a double injection of long-acting chloramphenicol (on admission to hospital and 48 h later) is as effective as a course… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
RANDOMISED COMPARISON OF CHLORAMPHENICOL, AMPICILLIN, CEFOTAXIME, AND CEFTRIAXONE FOR CHILDHOOD BACTERIAL MENINGITIS
TLDR
A 7-day course of ampicillin, cefotaxime, or ceftriaxone is sufficient in Hib, Mnc, or Pnc meningitis, and chloramphenicol was thus inferior to the other three antimicrobials. Expand
Warning-chloramphenicol may be good for your health.
TLDR
With the increasing number of reports of strains of H influenzae recovered from the cerebrospinal fluid that are resistant to ampicillin, chloramphenicol will play an even greater role in the therapy of bacterial meningitis. Expand
Single injection treatment of meningococcal meningitis. 2. Long-acting chloramphenicol.
TLDR
Long-acting chloramphenicol is an effective form of treatment for meningococcal meningitis and is likely to prove of particular value in the management of epidemics in areas with limited medical resources. Expand
Trial of Chloramphenicol for Meningitis in Northern Savanna of Africa
TLDR
It is suggested that chloramphenicol is a suitable alternative to sulphonamides for the treatment of meningococcal meningitis in those parts of Africa where the organism is sulphonamide-resistant. Expand
CHLORAMPHENICOL ALONE VERSUS CHLORAMPHENICOL PLUS PENICILLIN FOR BACTERIAL MENINGITIS IN CHILDREN
TLDR
In children with bacterial meningitis chloramphenicol alone given by intramuscular injection is as effective as chlorampenicol plus penicillin given intravenously. Expand
Selective primary health care: strategies for control of disease in the developing world. XIII. Acute bacterial meningitis.
TLDR
Three species of bacteria (Haemophilus influenzae type b, Neisseria meningitidis, and Streptococcus pneumoniae) cause approximately three-quarters of all cases of acute bacterial meningitis in industrialized and developing countries, and polysaccharide vaccines are ineffective in infants. Expand
Méningites bactériennes dans un hôpital pédiatrique en zone tropicale
TLDR
Dans 54,2% des cas une bacterie ou des antigenes solubles bacteriens ont ete mis en evidence resistantes a l'ampicilline ou au chloramphenicol. Expand
A multiple testing procedure for clinical trials.
TLDR
The overall size of the procedure is shown to be controlled with virtually the same accuracy as the single sample chi-square test based on N(m1 + m2) observations and the power is found to bevirtually the same. Expand
"Proving the null hypothesis" in clinical trials.
TLDR
Test statistics, confidence intervals, and sample size calculations are discussed, and the required sample size may be larger for either null hypothesis formulation than for the other, depending on the specific assumptions made. Expand
Traitement minute de la méningite cérébro-spinale épidémique par injection intramusculaire unique de chloramphénicol (suspension huileuse)*
TLDR
C'est ainsi qu'en Afrique sub-saharienne, dans les regions arides particulierement touchees par ces epidemies, la plupart des cas ne peuvent qu'etre traites sur place par des equipes sanitaires itinerantes. Expand
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