Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice

@inproceedings{Hsu2011LongTO,
  title={Long Tract of Untranslated CAG Repeats Is Deleterious in Transgenic Mice},
  author={Ren-Jun Hsu and Kuang-Ming Hsiao and Min-jon Lin and Chui-Yen Li and Lichun Wang and Luen-Kui Chen and Huichin Pan},
  booktitle={PloS one},
  year={2011}
}
The most frequent trinucleotide repeat found in human disorders is the CAG sequence. Expansion of CAG repeats is mostly found in coding regions and is thought to cause diseases through a protein mechanism. Recently, expanded CAG repeats were shown to induce toxicity at the RNA level in Drosophila and C. elegans. These findings raise the possibility that CAG repeats may trigger RNA-mediated pathogenesis in mammals. Here, we demonstrate that transgenic mice expressing EGFP transcripts with long… CONTINUE READING