Long-Term Transmission of Defective RNA Viruses in Humans and Aedes Mosquitoes

@article{Aaskov2006LongTermTO,
  title={Long-Term Transmission of Defective RNA Viruses in Humans and Aedes Mosquitoes},
  author={J. Aaskov and Katie Buzacott and H. M. Thu and Kym S Lowry and E. Holmes},
  journal={Science},
  year={2006},
  volume={311},
  pages={236 - 238}
}
In 2001, dengue virus type 1 (DENV-1) populations in humans and mosquitoes from Myanmar acquired a stop-codon mutation in the surface envelope (E) protein gene. Within a year, this stop-codon strain had spread to all individuals sampled. The presence of truncated E protein species within individual viral populations, along with a general relaxation in selective constraint, indicated that the stop-codon strain represents a defective lineage of DENV-1. We propose that such long-term transmission… Expand
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