Long-Term Serotonin Administration Induces Heart Valve Disease in Rats

@article{Gustafsson2005LongTermSA,
  title={Long-Term Serotonin Administration Induces Heart Valve Disease in Rats},
  author={Bj{\o}rn I. Gustafsson and Karin T{\o}mmer{\aa}s and Ivar Skj{\aa}k Nordrum and Jan P{\aa}l Loennechen and Anders Brunsvik and Erik Sollig{\aa}rd and Reidar Fossmark and Ingunn Bakke and Unni Syversen and Helge Lyder Waldum},
  journal={Circulation},
  year={2005},
  volume={111},
  pages={1517-1522}
}
Background—The purpose of this study was to investigate whether rats dosed with serotonin develop changes similar to those seen in human carcinoid heart disease. Methods and Results—Ten Sprague-Dawley rats were given serotonin injections subcutaneously once daily for 3 months; controls were given saline. A long-lasting hyperserotoninemia with a >10-fold increase in both platelet-poor plasma and dialysate from the femoral muscles appeared. The animals developed clinical signs such as flushing… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Expression of 5-hydroxytryptamine receptor subtype messenger RNA in interstitial cells from human heart valves.
TLDR
Preliminary evidence exists for the presence of distinct subsets of 5-HT receptors in human heart valves, indicating that interstitial cells of the valves potentially respond to serotonin levels. Expand
Cell proliferation in carcinoid valve disease: a mechanism for serotonin effects.
TLDR
Serotonin is a powerful mitogen for valvular subendocardial cells and at least partly mediated via 5HT1b receptors, and this mitogenic effect was inhibited by methiotepin but not ketanserin. Expand
Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography.
TLDR
Serotonin plays a major role in the pathogenesis of the cardiac plaque formation observed in carcinoid patients, and data suggest that heart disease patients demonstrated strikingly higher serotonin levels than noncardiac patients. Expand
Carcinoid heart disease: the role of urinary 5-hydroxyindoleacetic acid excretion and plasma levels of atrial natriuretic peptide, transforming growth factor-beta and fibroblast growth factor.
TLDR
High levels of 5-HIAA excretion and plasma ANP were found to be associated with carcinoid heart disease, and no significant relation with TGF-beta or FGF was found. Expand
Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.
TLDR
These studies of the signal transduction activity of SAVICs in response to 5-HT have demonstrated that the5-HT(2A)Rs are the most functionally active of the 5- HT(2)Rs in this cell type. Expand
Carcinoid heart disease: relationship of circulating vasoactive substances to ultrasound-detectable cardiac abnormalities.
TLDR
Right heart disease seems to be present more often than previously reported in patients with malignant midgut carcinoid tumors, and the severity of cardiac involvement does not seem to be related to the duration of carcinoid disease but more to the extent of the disease, i.e., higher plasma levels of serotonin and tachykinins. Expand
Factors associated with progression of carcinoid heart disease.
TLDR
Serotonin is related to the progression of carcinoid heart disease, and the risk of progressive heart disease is higher in patients who receive chemotherapy than in those who do not, according to a retrospective study conducted to identify such factors. Expand
Mitogenic effect of serotonin on vascular endothelial cells.
TLDR
5-HT is a mitogen for endothelial cells at concentrations likely to be present at sites of vascular injury and mediated via the 5-HT2 receptor, which is coupled to a G protein. Expand
Effects of Cariporide and Losartan on Hypertrophy, Calcium Transients, Contractility, and Gene Expression in Congestive Heart Failure
TLDR
Losartan has salutary effects on postinfarction remodeling and gene expression, whereas cariporide is neutral, and improve cardiomyocyte contractility and calcium regulation in chronic heart failure. Expand
Ablation of Serotonin 5-HT2B Receptors in Mice Leads to Abnormal Cardiac Structure and Function
TLDR
For the first time, strong genetic evidence that serotonin, via the 5-HT2B receptor, regulates cardiac structure and function is found. Expand
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