Long-Term Reduction in Ventral Tegmental Area Dopamine Neuron Population Activity Following Repeated Stimulant or Ethanol Treatment

@article{Shen2007LongTermRI,
  title={Long-Term Reduction in Ventral Tegmental Area Dopamine Neuron Population Activity Following Repeated Stimulant or Ethanol Treatment},
  author={Roh-Yu Shen and Kar-Chan Choong and Alexis C. Thompson},
  journal={Biological Psychiatry},
  year={2007},
  volume={61},
  pages={93-100}
}
BACKGROUND Drugs of abuse exert profound effects on the mesolimbic/mesocortical dopaminergic (DA) systems. Few studies have investigated the long-term adaptations in ventral tegmental area (VTA) DA neuron activity after repeated exposure to drugs of abuse. We investigated changes in the electrical activity of VTA DA neurons after cessation from treatment with several stimulants and ethanol. METHODS Adult rats were treated with stimulants (amphetamine: 2 mg/kg per day, 5 days/week, 2 weeks… CONTINUE READING

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