Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline.

  title={Long-Term Pulmonal Therapy of Cystic Fibrosis-Patients with Amitriptyline.},
  author={Constantin Adams and Vanya Icheva and Caroline Deppisch and Josefine Lauer and Gloria Herrmann and Ute Graepler-Mainka and Susanne Heyder and Erich Gulbins and Joachim Riethmueller},
  journal={Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology},
  volume={39 2},
BACKGROUND/AIMS Several recent clinical studies revealed an accumulation of ceramide in bronchial epithelial cells of patients with cystic fibrosis (CF). Degradation of ceramide concentrations in lungs of CF patients employing the functional acid sphingomyelinase inhibitor amitriptyline revealed a benefit in lung function, weight and exacerbation rates… CONTINUE READING