Long-Term Pharmacotherapy for Post-Traumatic Stress Disorder

@article{Davis2006LongTermPF,
  title={Long-Term Pharmacotherapy for Post-Traumatic Stress Disorder},
  author={Lori L. Davis and Elizabeth C Frazier and Raela B Williford and Jason M. Newell},
  journal={CNS Drugs},
  year={2006},
  volume={20},
  pages={465-476}
}
This article reviews the literature on the long-term pharmacological treatment of post-traumatic stress disorder (PTSD). A PUBMED search was conducted; only studies on the effects of long-term (>14-weeks) pharmacological treatment for PTSD in adults or children were considered. Our search identified three randomised, double-blind, placebo-controlled studies (one each for sertraline, fluoxetine and risperidone), four open-label studies (one each for sertraline, paroxetine, nefazodone and… 
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References

SHOWING 1-10 OF 31 REFERENCES
Pharmacotherapy for post-traumatic stress disorder: a comprehensive review
TLDR
There are virtually no data on pharmacotherapy for acute stress reaction or for PTSD in children, and future directions for research may focus on combination treatment in the more treatment-resistant patient populations.
Sertraline treatment of posttraumatic stress disorder: results of 24 weeks of open-label continuation treatment.
TLDR
The acute efficacy of sertraline is sustained in the vast majority of patients, and at least half of nonresponders to acute treatment will eventually respond to continued treatment.
Efficacy and safety of sertraline treatment of posttraumatic stress disorder: a randomized controlled trial.
TLDR
The data suggest that sertraline is a safe, well-tolerated, and effective treatment for PTSD.
Posttraumatic stress disorder and quality of life: results across 64 weeks of sertraline treatment.
TLDR
Sertraline treatment of chronic PTSD is associated with rapid improvement in quality of life that is progressive and sustained over the course of more than 1 year of treatment.
Treatment-Resistant Posttraumatic Stress Disorder: Strategies for Intervention
TLDR
This review will address representative existing studies and discuss several potential pharmacologic strategies for patients suffering from treatment refractory PTSD.
Multicenter, double-blind comparison of sertraline and placebo in the treatment of posttraumatic stress disorder.
TLDR
The results of the current study suggest that sertraline is a safe, well-tolerated, and significantly effective treatment for PTSD.
Sertraline: A Review of its Therapeutic Use in Post-Traumatic Stress Disorder
TLDR
Sertraline has demonstrated efficacy in the treatment of PTSD, particularly in female patients and in non-combat-induced PTSD, and is generally well tolerated, and appears to have a lower potential for drug interactions than other SSRIs, although direct comparisons are lacking.
Fluoxetine v. placebo in prevention of relapse in post-traumatic stress disorder
TLDR
Fluoxetine is effective and well tolerated in the prevention of PTSD relapse for up to 6 months and is less likely to relapse than patients in the fluoxettine/placebo group.
Efficacy of sertraline in preventing relapse of posttraumatic stress disorder: results of a 28-week double-blind, placebo-controlled study.
TLDR
Evidence is provided for the ability of sertraline both to sustain improvement in PTSD symptoms and to provide prophylactic protection against relapse in patients with posttraumatic stress disorder who had completed a 12-week double-blind, placebo-controlled acute treatment study and a subsequent 24-week open-label study of continuation treatment with sertrals.
WCA Recommendations for the Long-Term Treatment of Posttraumatic Stress Disorder
TLDR
Treatment for PTSD includes psychotherapy and pharmacotherapy, which includes selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, and monoamine oxidase inhibitors, which have been proven effective and safe in long-term randomized controlled trials.
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