Long-Term Outcome of Initially Unresectable Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Followed by Radical Surgery of Metastases

@article{Masi2009LongTermOO,
  title={Long-Term Outcome of Initially Unresectable Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil/Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Followed by Radical Surgery of Metastases},
  author={Gianluca Masi and Fotios Loupakis and Luca Emanuele Pollina and Enrico Vasile and S Cupini and Sergio Ricci and Isa Maura Brunetti and Roberta Ferraldeschi and Giuseppe Naso and Franco Filipponi and Andrea Pietrabissa and Orlando Goletti and Giacomo Giulio Baldi and Lorenzo Fornaro and Michele Andreuccetti and Alfredo Falcone},
  journal={Annals of Surgery},
  year={2009},
  volume={249},
  pages={420-425}
}
OBJECTIVE/BACKGROUND The GONO-FOLFOXIRI regimen improved the rate of R0 secondary resection of metastases in initially unresectable metastatic colorectal cancer. [] Key MethodPATIENTS AND METHODS Overall, 196 patients with initially unresectable metastatic colorectal cancer were treated with FOLFOXIRI in 2 phase II and 1 phase III trial. This regimen was associated with an elevated response rate (70.4%) and 37 patients (19%) could undergo a secondary R0 surgery on metastases.

FOLFOX enables high resectability and excellent prognosis for initially unresectable colorectal liver metastases.

FOLFOX is an effective chemotherapeutic regimen leading to successful hepatic resection and an excellent prognosis for patients with initially CRLM.

Assessment of Tumor Response and Resection Rates in Unresectable Colorectal Liver Metastases Following Neoadjuvant Chemotherapy with Cetuximab

To investigate efficacy and safety of cetuximab combined with neo adjuvant chemotherapy regimen in patients with unresectable colorectal liver. This was a prospective trial with rate of Ro liver

Patients Operated On for Initially Unresectable Colorectal Liver Metastases With Missing Metastases Experience a Favorable Long-Term Outcome

Highly chemosensitive patients, whose initially unresectable CRL Ms become resectable because of missing CRLMs left in place, have a favorable long-term outcome.

Histopathologic evaluation of liver metastases from colorectal cancer in patients treated with FOLFOXIRI plus bevacizumab

The addition of bevacizumab to FOLFOXIRI produces high rates of pathologic responses and necrosis of CLM without increasing liver toxicity.

Chance of Cure Following Liver Resection for Initially Unresectable Colorectal Metastases: Analysis of Actual 5-Year Survival

Cure can be achieved in about 23 % of patients resected for initially unresectable CRLM downsized by chemotherapy, and Liver resection can be safely performed in selected patients even after multiple courses of chemotherapy.

Preoperative treatment with bevacizumab in combination with chemotherapy in patients with unresectable metastatic colorectal carcinoma

Preoperative bevacizumab-based chemotherapy offers a high surgical rescue rate in patients with initially unresectable mCRC.

Randomized trial of two induction chemotherapy regimens in metastatic colorectal cancer: an updated analysis.

Six months of induction chemotherapy with FOLFOXIRI is associated with a clinically significant improvement in the long-term outcome compared with F OLFIRI with an absolute benefit in survival at 5 years of 7%.

A multicentre study of capecitabine, oxaliplatin plus bevacizumab as perioperative treatment of patients with poor-risk colorectal liver-only metastases not selected for upfront resection.

  • R. WongD. Cunningham I. Chau
  • Medicine
    Annals of oncology : official journal of the European Society for Medical Oncology
  • 2011
Neoadjuvant CAPOX plus bevacizumab resulted in a high response rate for patients with CLMs with poor-risk features not selected for upfront resection and converted 40% of patients to resectability.
...

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