Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc)

@article{MancoJohnson2013LongTermOE,
  title={Long-Term Orthopedic Effects Of Delaying Prophylaxis In Severe Hemophilia A Until Age 6 Years: Results Of The Joint Outcome Study Continuation (JOSc)},
  author={M. Manco-Johnson and T. Blades and S. Funk and H. Lane and K. McRedmond and A. Dunn and M. Recht and A. Shapiro and L. Valentino and Deborah L. Brown},
  journal={Blood},
  year={2013},
  volume={122},
  pages={210-210}
}
The Joint Outcome Study (JOS) was a randomized controlled clinical trial in boys with severe factor VIII deficiency comparing prophylaxis consisting of 25 IU/kg factor VIII every other day begun prior to age 30 months with an enhanced episodic regimen given only in response to bleeding. At JOS exit at age 6 years, joint outcome by sensitive magnetic resonance image (MRI) and joint physical examination (PE) of 6 index joints (both ankles, knees and elbows) determined superiority of prophylaxis… Expand
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