Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex.

@article{Kim2016LongTermOA,
  title={Long-Term Optical Access to an Estimated One Million Neurons in the Live Mouse Cortex.},
  author={Tony Hyun Kim and Yanping Zhang and J{\'e}r{\^o}me A. Lecoq and Juergen C. Jung and Jane Li and Hongkui Zeng and Cristopher M. Niell and Mark J. Schnitzer},
  journal={Cell reports},
  year={2016},
  volume={17 12},
  pages={
          3385-3394
        }
}
  • Tony Hyun Kim, Yanping Zhang, +5 authors Mark J. Schnitzer
  • Published 2016
  • Biology, Medicine
  • Cell reports
  • A major technological goal in neuroscience is to enable the interrogation of individual cells across the live brain. By creating a curved glass replacement to the dorsal cranium and surgical methods for its installation, we developed a chronic mouse preparation providing optical access to an estimated 800,000-1,100,000 individual neurons across the dorsal surface of neocortex. Post-surgical histological studies revealed comparable glial activation as in control mice. In behaving mice expressing… CONTINUE READING

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