Long-Term Functional Side-Effects of Stimulants and Sedatives in Drosophila melanogaster

  title={Long-Term Functional Side-Effects of Stimulants and Sedatives in Drosophila melanogaster},
  author={Kennedy C. Matsagas and David B. L. Lim and Marc A. Horwitz and Cristina L. Rizza and Laurence D. Mueller and Bryant Villeponteau and Michael G. Rose},
  booktitle={PloS one},
BACKGROUND Small invertebrate animals, such as nematodes and fruit flies, are increasingly being used to test candidate drugs both for specific therapeutic purposes and for long-term health effects. Some of the protocols used in these experiments feature such experimental design features as lifelong virginity and very low densities. By contrast, the ability of both fruit flies and nematodes to resist stress is frequently correlated with their longevity and other functional measures, suggesting… CONTINUE READING


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