Corpus ID: 88839995

Long-Term Exposure of Sildenafil Citrate on Sperm Parameters in Rat

@article{Suresh2011LongTermEO,
  title={Long-Term Exposure of Sildenafil Citrate on Sperm Parameters in Rat},
  author={Sekar Suresh and Elumali Prithiviraj and Nagella Venkatalakshmi and Mohanraj Karthik Ganesh and Lakshmanan Ganesh and Hyun-Jeong Lee and Seppan Prakash},
  journal={Reproductive and developmental Biology},
  year={2011},
  volume={35},
  pages={435-439}
}
Sildenafil citrate (SIL) a phosphodiesterase 5 inhibitor (PDE5I) has been used for long time as a first line oral drug for erectile dysfunction. Though it has beneficial effects on erectile organ it also has some adverse effects in other cells and/or tissues related to reproductive system when exposed to longer duration. The objective of the present study is to evaluate the long term effect of SIL on sperm parameters in Wistar albino rat. The animals are divided into two groups, for group I… Expand
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TLDR
It is found that Cinnamomum cassia extract was effective in management of sexual dysfunction in aged rats and hence a possible mechanism of action is proposed which could be responsible for restoring sexual activity in aged rat. Expand