Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain

  title={Long-Term Environmental Enrichment Leads to Regional Increases in Neurotrophin Levels in Rat Brain},
  author={Brian Ickes and Therese M. Pham and Linda A. Sanders and David S. Albeck and Abdul Kadir H Mohammed and Ann-Charlotte Granholm},
  journal={Experimental Neurology},
A number of studies have demonstrated that both morphological and biochemical indices in the brain undergo alterations in response to environmental influences. In previous work we have shown that rats raised in an enriched environmental condition (EC) perform better on a spatial memory task than rats raised in isolated conditions (IC). We have also found that EC rats have a higher density of immunoreactivity than IC rats for both low and high affinity nerve growth factor (NGF) receptors in the… 
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