Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo

  title={Long-Term Endurance Exercise in Humans Stimulates Cell Fusion of Myoblasts along with Fusogenic Endogenous Retroviral Genes In Vivo},
  author={Sebastian Frese and Matthias Ruebner and Frank Suhr and Thierry M. Konou and Kim A. Tappe and Marco Toigo and Hans Heinrich Jung and Christine Henke and Ruth Steigleder and Pamela L. Strissel and Hanna Huebner and Matthias Wilhelm Beckmann and Piet van der Keylen and Benedikt Schoser and Thorsten Schiffer and Laura Frese and Wilhelm Bloch and Reiner Strick},
  journal={PLoS ONE},
Myogenesis is defined as growth, differentiation and repair of muscles where cell fusion of myoblasts to multinucleated myofibers is one major characteristic. Other cell fusion events in humans are found with bone resorbing osteoclasts and placental syncytiotrophoblasts. No unifying gene regulation for natural cell fusions has been found. We analyzed skeletal muscle biopsies of competitive cyclists for muscle-specific attributes and expression of human endogenous retrovirus (ERV) envelope genes… 

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