Long-Term Efficacy and Safety of Tretinoin Emollient Cream 0.05% in the Treatment of Photodamaged Facial Skin

@article{Kang2005LongTermEA,
  title={Long-Term Efficacy and Safety of Tretinoin Emollient Cream 0.05\% in the Treatment of Photodamaged Facial Skin},
  author={Sewon Kang and Wilma Fowler Bergfeld and Alice B. Gottlieb and Janet G. Hickman and J M Humeniuk and Steven E. Kempers and Mark G. Lebwohl and Nick J. Lowe and Amy J. McMichael and James Milbauer and Tania J. Phillips and Jerold Powers and David Rodriguez and Ronald Savin and Joel S. Shavin and Daniel W Sherer and Nancy G. Silvis and R Weinstein and Jonathan S. Weiss and Craig Hammerberg and Gary J. Fisher and Marge Nighland and Rachel M. Grossman and Judit Nyirady},
  journal={American Journal of Clinical Dermatology},
  year={2005},
  volume={6},
  pages={245-253}
}
AbstractBackground: Long-term (>1 year) placebo-controlled studies of tretinoin in the treatment of photodamaged skin have not been conducted. Recently, we conducted a 2-year placebo-controlled study of tretinoin emollient cream 0.05%, including histopathologic assessment of safety and analysis of markers of collagen deposition. Objective: The objective of the study was to determine the long-term safety and efficacy of tretinoin emollient cream 0.05% in the treatment of moderate to severe… 

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