Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants

@article{Fischer2016LongTermEO,
  title={Long-Term Effects of the Collagenase of the Bacterium Clostridium histolyticum for the Treatment of Capsular Fibrosis After Silicone Implants},
  author={Sebastian Fischer and Yannick F. Diehm and Thomas Henzler and Martin R Berger and Jonas Kolbenschlag and Anne Latz and Ericka Bueno and Christoph Hirche and Ulrich Kneser and Bohdan Pomahac},
  journal={Aesthetic Plastic Surgery},
  year={2016},
  volume={41},
  pages={211-220}
}
Capsular contracture remains the most frequent long-term complication after augmentation mammoplasty with silicone implants. Thereby, the main part of the fibrotic capsule is collagen. The collagenase of the bacterium Clostridium histolyticum is approved for the treatment of fibrotic diseases and has been demonstrated to be effective for capsular fibrosis treatment in the short term. However, long-term effectiveness is currently unknown but mandatory for clinical utilization. Forty-eight rats… CONTINUE READING
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