Long-Term Effects of Safinamide on Mood Fluctuations in Parkinson’s Disease

  • Ioannis Kottakisa
  • Published 2017


Background: Mood disorders are very frequent in Parkinson’s Disease (PD), and their effective treatment is still a major unresolved issue: growing evidence suggests that glutamatergic system dysfunction is directly involved. Safinamide is a drug with an innovative mechanism of action, dopaminergic and non-dopaminergic, that includes the reversible… (More)


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