Long-Term Effects of Mild Oligonephronia Induced In Utero by Gentamicin in the Rat

Abstract

ABSTRACT: Renal clearance studies and morphologic observations were performed in rats aged 14, 21, and 28 d and 3, 6, 9, and 12 mo born with a 20% reduction in nephron number after administration of 75 mg/kg/d of gentamicin to their mothers during the second half of gestation. Gentamicin was still present in urine 3 mo after birth. Morphologic damage… (More)
DOI: 10.1203/00006450-199111000-00011

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