Long-Term Depression Properties in a Simple System

@article{Goda1996LongTermDP,
  title={Long-Term Depression Properties in a Simple System},
  author={Yukiko Goda and Charles F. Stevens},
  journal={Neuron},
  year={1996},
  volume={16},
  pages={103-111}
}
Long-term depression (LTD) in pairs of cultured rodent hippocampal neurons was examined to study the molecular basis of this form of synaptic plasticity. We have previously characterized two components of transmitter release: a synchronous, fast phase that requires synaptotagmin I, and an asynchronous, slow component that persists in the absence of synaptotagmin I. Are these two release components differentially affected by the presynaptic changes of LTD, or is the mechanism of plasticity… CONTINUE READING
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