Long-Term Bone Density Evaluation in Cerebrotendinous Xanthomatosis: Evidence of Improvement after Chenodeoxycholic Acid Treatment

@article{Martini2012LongTermBD,
  title={Long-Term Bone Density Evaluation in Cerebrotendinous Xanthomatosis: Evidence of Improvement after Chenodeoxycholic Acid Treatment},
  author={Giuseppe Martini and Andrea Mignarri and Martina Ruvio and Roberto Valenti and Beatrice Franci and Marina Del Puppo and Antonio Federico and Ranuccio Nuti and Maria Teresa Dotti},
  journal={Calcified Tissue International},
  year={2012},
  volume={92},
  pages={282-286}
}
Cerebrotendinous xanthomatosis (CTX) is known to be associated with osteoporosis and a higher incidence of bone fractures. However, the underlying pathogenesis is still unknown, and the effects of long-term replacement therapy with chenodeoxycholic acid (CDCA) on bone mineral density (BMD) have not been fully investigated. We studied 11 CTX patients aged 13–43 years. We performed dual-energy X-ray absorptiometry and assessed serum cholestanol and 25-hydroxyvitamin D (25-OHD) concentrations both… CONTINUE READING

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