Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons

@inproceedings{Yao2012LongSD,
  title={Long Span DNA Paired-End-Tag (DNA-PET) Sequencing Strategy for the Interrogation of Genomic Structural Mutations and Fusion-Point-Guided Reconstruction of Amplicons},
  author={Fei Fei Yao and Pramila Nuwantha Ariyaratne and Axel M Hillmer and Wah Heng Charlie Lee and Guoliang Li and Audrey S. M. Teo and Xing Yi Woo and Zhenshui Zhang and Jieqi P. Chen and Wan Ting Poh and Kelson Folkvard Braaten Zawack and Chee Seng Chan and See Ting Leong and Say Chuan Neo and Poh Sum D. Choi and Song Gao and Niranjan Nagarajan and Herv{\'e} Thoreau and Atif Shahab and Xiaoan Ruan and Val{\`e}re Cacheux-Rataboul and Chia-Lin Wei and Guillaume Bourque and Wing-Kin Sung and Edison T. Liu and Yijun Ruan},
  booktitle={PloS one},
  year={2012}
}
Structural variations (SVs) contribute significantly to the variability of the human genome and extensive genomic rearrangements are a hallmark of cancer. While genomic DNA paired-end-tag (DNA-PET) sequencing is an attractive approach to identify genomic SVs, the current application of PET sequencing with short insert size DNA can be insufficient for the comprehensive mapping of SVs in low complexity and repeat-rich genomic regions. We employed a recently developed procedure to generate PET… CONTINUE READING
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