Long-Range Directional Movement of an Interphase Chromosome Site

@article{Chuang2006LongRangeDM,
  title={Long-Range Directional Movement of an Interphase Chromosome Site},
  author={Chien-Hui Chuang and A. Carpenter and B. Fuchsov{\'a} and T. Johnson and P. Lanerolle and A. Belmont},
  journal={Current Biology},
  year={2006},
  volume={16},
  pages={825-831}
}
Increasing evidence suggests functional compartmentalization of interphase nuclei. This includes preferential interior localization of gene-rich and early replicating chromosome regions versus peripheral localization of gene-poor and late replicating chromosome regions , association of some active genes with nuclear speckles or transcription "factories", and association of transcriptionally repressed genes with heterochromatic regions. Dynamic changes in chromosome compartmentalization imply… Expand
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