Long QT syndromes and torsade de pointes

@article{Viskin1999LongQS,
  title={Long QT syndromes and torsade de pointes},
  author={Sami Viskin},
  journal={The Lancet},
  year={1999},
  volume={354},
  pages={1625-1633}
}
In the long QT syndromes (LQTS), malfunction of ion channels impairs ventricular repolarisation and triggers a characteristic ventricular tachyarrhythmia: torsade de pointes. Symptoms in the LQTS (syncope or cardiac arrest) are caused by this arrhythmia. In congenital LQTS, mutations in the genes encoding for ion channels cause this channel malfunction. Six genotypes (LQT1 to LQT6) have been identified, and attempts are being made to correlate different mutations with clinical signs and… CONTINUE READING
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