Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.

@article{Betts2017LongNR,
  title={Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.},
  author={Joshua A. Betts and Mahdi Moradi Marjaneh and Fares Al-Ejeh and Yi Chieh Lim and Wei Shi and Haran Sivakumaran and Romain Trop{\'e}e and Ann-Marie Patch and Michael B. Clark and Nenad Bartonicek and A P Wiegmans and Kristine M. Hillman and Susanne Kaufmann and Amanda L. Bain and Brian S. Gloss and Joanna Crawford and Stephen H. Kazakoff and Shivangi Wani and Shu wen Wen and Bryan William Day and Andreas M{\"o}ller and Nicole Cloonan and John V. Pearson and Melissa A. Brown and Timothy R Mercer and Nicola Waddell and Kum Kum Khanna and Eloise Dray and Marcel E. Dinger and Stacey L. Edwards and Juliet D. French},
  journal={American journal of human genetics},
  year={2017},
  volume={101 2},
  pages={255-266}
}
Breast cancer risk is strongly associated with an intergenic region on 11q13. We have previously shown that the strongest risk-associated SNPs fall within a distal enhancer that regulates CCND1. Here, we report that, in addition to regulating CCND1, this enhancer regulates two estrogen-regulated long noncoding RNAs, CUPID1 and CUPID2. We provide evidence… CONTINUE READING