Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.

Abstract

Basal p53 levels are tightly suppressed under normal conditions. Disrupting this regulation results in elevated p53 levels to induce cell cycle arrest, apoptosis, and tumor suppression. Here, we report the suppression of basal p53 levels by a nuclear, p53-regulated long noncoding RNA that we termed PURPL (p53 upregulated regulator of p53 levels). Targeted… (More)
DOI: 10.1016/j.celrep.2017.08.041

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@article{Li2017LongNR, title={Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer.}, author={Xiao Li and Murugan Subramanian and Matthew F. Jones and Ritu S Chaudhary and Deepak Kumar Singh and Xinying Zong and Berkley E. Gryder and Sivasish Sindri and Min Mo and Aaron J. Schetter and Xinyu Wen and Swetha Parvathaneni and Dickran Kazandjian and Lisa M. Miller Jenkins and Wei Tang and Fathi Elloumi and Jennifer L Martindale and Maite Huarte and Yuelin Zhu and Ana I. Robles and Susan M Frier and Frank Rigo and M Olcay Çam and Stefan Ambs and Sudha Sharma and Curtis C. Harris and Mary Dasso and Kannanganattu V Prasanth and Ashish Nandan Lal}, journal={Cell reports}, year={2017}, volume={20 10}, pages={2408-2423} }