Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5.

@article{Xie2018LongNR,
  title={Long Noncoding RNA ITPRIP-1 Positively Regulates the Innate Immune Response through Promotion of Oligomerization and Activation of MDA5.},
  author={Qinya Xie and Shengwen Chen and Renyun Tian and Xiang Huang and Rilin Deng and Binbin Xue and Yuwen Qin and Yan Xu and Jingjing Wang and Mengmeng Guo and Jinwen Chen and Songqing Tang and Guangdi Li and Haizhen Zhu},
  journal={Journal of virology},
  year={2018},
  volume={92 17}
}
Emerging evidence indicates that long noncoding RNAs (lncRNAs) regulate various biological processes, especially innate and adaptive immunity. However, the relationship between lncRNAs and the interferon (IFN) pathway remains largely unknown. Here, we report that lncRNA ITPRIP-1 (lncITPRIP-1) is involved in viral infection and plays a crucial role in the virus-triggered IFN signaling pathway through the targeting of melanoma differentiation-associated gene 5 (MDA5). LncITPRIP-1 can be induced… CONTINUE READING