Long Noncoding RNA-GAS5: A Novel Regulator of Hypertension-Induced Vascular Remodeling.

@article{Wang2016LongNR,
  title={Long Noncoding RNA-GAS5: A Novel Regulator of Hypertension-Induced Vascular Remodeling.},
  author={Yang-Ning-Zhi Wang and Kun Shan and Mu-Di Yao and Jin Gui Yao and Jia-jian Wang and Xiang Li and Ban Liu and Yang-yang Zhang and Yong Ji and Qin Jiang and Biao Yan},
  journal={Hypertension},
  year={2016},
  volume={68 3},
  pages={736-48}
}
Vascular remodeling is an important pathological feature of hypertension, leading to increased vascular resistance and reduced compliance. Endothelial cell (EC) and vascular smooth muscle cell (VSMC) dysfunction is involved in vascular remodeling. Long noncoding RNAs are potential regulators of EC and VSMC function. Herein, we determined whether long noncoding RNA-growth arrest-specific 5 (GAS5) is involved in hypertension-related vascular remodeling. We revealed that GAS5 knockdown aggravated… CONTINUE READING
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