Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell-Specific Long Noncoding RNAs.

@article{Tayari2016LongNR,
  title={Long Noncoding RNA Expression Profiling in Normal B-Cell Subsets and Hodgkin Lymphoma Reveals Hodgkin and Reed-Sternberg Cell-Specific Long Noncoding RNAs.},
  author={Mina Masoumeh Tayari and Melanie Winkle and Gertrud Kortman and Jantine G. Sietzema and Debora de Jong and Miente Martijn Terpstra and Pieter Mestdagh and Fransciscus Gerardus Maria Kroese and Lydia Visser and Arjan Diepstra and Klaas Kok and Anke van den Berg and Joost Laurens Kluiver},
  journal={The American journal of pathology},
  year={2016},
  volume={186 9},
  pages={
          2462-72
        }
}
Hodgkin lymphoma (HL) is a malignancy of germinal center (GC) B-cell origin. To explore the role of long noncoding RNAs (lncRNAs) in HL, we studied lncRNA expression patterns in normal B-cell subsets, HL cell lines, and tissues. Naive and memory B cells showed a highly similar lncRNA expression pattern, distinct from GC-B cells. Significant differential expression between HL and normal GC-B cells was observed for 475 lncRNA loci. For two validated lncRNAs, an enhanced expression was observed in… CONTINUE READING
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