Corpus ID: 54019306

Long Non-coding RNA ZEB 1-AS 1 Promotes Tumorigenesis and Metastasis in Colorectal Cancer

  title={Long Non-coding RNA ZEB 1-AS 1 Promotes Tumorigenesis and Metastasis in Colorectal Cancer},
  author={Hajar Rezanejad Bardaji and Malek Hossein Asadi and Mohammad Yaghoobi},
Emerging evidence implicates that a large fraction of human genome was transcribed but the transcripts known as long non-coding RNA are not translated into proteins. They are contributing in different cellular processes, including cellular proliferation and apoptosis. LncRNAs were found to play critical roles in many diseases and act as key regulators in malignancies. In this study, we investigated the expression and clinical significance of ZEB1AS1 in colorectal cancer. In the present study… Expand

Figures and Tables from this paper


Long noncoding RNA VIM-AS1 promotes colorectal cancer progression and metastasis by inducing EMT.
The findings of this study suggest that VIM-AS1 promotes tumor growth and metastasis by inducing EMT in CRC cells and could be considered as a novel tumor marker with probable value in diagnosis and CRC treatment. Expand
A Long Noncoding RNA ZEB1-AS1 Promotes Tumorigenesis and Predicts Poor Prognosis in Glioma
  • Q. Lv, Lei Hu, +7 authors H. Zhou
  • Biology, Medicine
  • International journal of molecular sciences
  • 2016
ZEB1-AS1 functioned as an important regulator of migration and invasion via activating epithelial to mesenchymal transition (EMT) through up-regulating the expression of ZEB1, MMP2, M MP9, N-cadherin, and Integrin-β1 as well as decreasing E-c cadherin levels in the metastatic progression of glioma. Expand
Overexpressed lncRNA ZEB 1-AS 1 promotes cell invasion and angiogenesis through Wnt / β-catenin signaling in non-small cell lung cancer
Background: Increasing evidences showed that lncRNAs were aberrantly expressed and acted as key regulators in tumor progression. LncRNA ZEB1-AS1 has been found to be upregulated and acted as anExpand
Upregulation of long noncoding RNA ZEB1-AS1 promotes tumor metastasis and predicts poor prognosis in hepatocellular carcinoma
The results provide novel insights into the function of lncRNA-driven hepatocarcinogenesis, highlight the important role of ZEB1-AS1 and Z EB1 in HCC progression, and indicate that ZEB- AS1 may be served as a valuable prognostic biomarker for HCC. Expand
Long noncoding RNA ZEB 1-AS 1 acts as an oncogene in osteosarcoma by epigenetically activating ZEB 1
Long noncoding RNAs (lncRNAs) have been demonstrated to be dysregulated in many disease states and have pivotal roles in various pathophysiological processes. However, the expression, roles andExpand
Expression of long non-coding RNA ZEB1-AS1 in esophageal squamous cell carcinoma and its correlation with tumor progression and patient survival.
Results indicated that lncRNA ZEB1-AS1 was associated with tumor progression and could be an independent prognostic factor for ESCC patients. Expand
Up-regulation of long non-coding RNA XLOC_010235 regulates epithelial-to-mesenchymal transition to promote metastasis by associating with Snail1 in gastric cancer
Understanding is advanced of the role of lncRNA XLOC_010235 as a active regulator of EMT by associating with Snail1, which may help in the development of new therapeutics. Expand
Role of the long non-coding RNA HOTAIR in hepatocellular carcinoma
The potential use of HOTAIR as a biomarker to achieve more accurate prognostic predictions and as an effective therapeutic target for HCC is discussed. Expand
MIAT lncRNA is overexpressed in breast cancer and its inhibition triggers senescence and G1 arrest in MCF7 cell line
The results suggest that MIAT involved in breast cancer progression and could be candidate as a novel tumor marker for diagnosis and treatment of breast cancer. Expand
PCA3 long noncoding RNA modulates the expression of key cancer-related genes in LNCaP prostate cancer cells
Evidence is provided that PCA3 silencing modulates the expression of key cancer-related genes, including those coding for AR cofactors and EMT markers, which is consistent with a putative therapeutic approach to inhibit PCa growth. Expand