Long Non-coding RNA XIST May Influence Cervical Ossification of the Posterior Longitudinal Ligament Through Regulation of miR-17-5P/AHNAK/BMP2 Signaling Pathway

@article{Liao2019LongNR,
  title={Long Non-coding RNA XIST May Influence Cervical Ossification of the Posterior Longitudinal Ligament Through Regulation of miR-17-5P/AHNAK/BMP2 Signaling Pathway},
  author={Xinyuan Liao and Dezhi Tang and Hai-song Yang and Yu Chen and De-yu Chen and Lianshun Jia and Lili Yang and Xiongsheng Chen},
  journal={Calcified Tissue International},
  year={2019},
  volume={105},
  pages={670 - 680}
}
Long non-coding RNAs (lncRNAs) play an important role in the development of bone-related diseases. This study was conducted to investigate the role and mechanism of lncRNA X inactive specific transcript (XIST) in the occurrence of cervical ossification of the posterior longitudinal ligament (OPLL). Here, primary human ligament fibroblasts cells (LFCs) were isolated from 30 cases of OPLL and 30 normal cervical posterior longitudinal ligament (non-OPLL) tissues to perform the qPCR and Western… CONTINUE READING