Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.

  title={Long-Lived Plasma Cells Are Contained within the CD19(-)CD38(hi)CD138(+) Subset in Human Bone Marrow.},
  author={Jessica L. Halliley and Christopher M Tipton and Jane L Liesveld and Alexander F. Rosenberg and Jaime Darce and Ivan V Gregoretti and Lana Popova and Denise A. Kaminiski and Christopher F Fucile and Igor Albizua and Shuya Y. Kyu and K Y Chiang and Kyle T. Bradley and Richard Burack and Mark K. Slifka and Erika K Hammarlund and Hao Wu and Liping Zhao and Edward E. Walsh and Ann R Falsey and Troy D. Randall and Wan Cheung Cheung and Ig{\~n}acio Sanz and F. Eun-Hyung Lee},
  volume={43 1},
Antibody responses to viral infections are sustained for decades by long-lived plasma cells (LLPCs). However, LLPCs have yet to be characterized in humans. Here we used CD19, CD38, and CD138 to identify four PC subsets in human bone marrow (BM). We found that the CD19(-)CD38(hi)CD138(+) subset was morphologically distinct, differentially expressed PC-associated genes, and exclusively contained PCs specific for viral antigens to which the subjects had not been exposed for more than 40 years… CONTINUE READING
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