Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens

@article{Garsin2003LongLivedCE,
  title={Long-Lived C. elegans daf-2 Mutants Are Resistant to Bacterial Pathogens},
  author={Danielle A. Garsin and Jacinto Villanueva and Jakob Begun and Dennis H. Kim and Costi D. Sifri and Stephen B. Calderwood and Gary Ruvkun and Frederick M. Ausubel},
  journal={Science},
  year={2003},
  volume={300},
  pages={1921 - 1921}
}
Our laboratories have studied the mechanisms of aging ( [1][1], [2][2] ) and immune function ( [3][3] ) in Caenorhabditis elegans . Herein we show that the mechanisms that govern these two processes may be interrelated. The human Gram-negative bacterial pathogens Pseudomonas aeruginosa and 
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539 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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539 Citations

Signaling in the immune response.

  • J. Ewbank
  • Biology
    WormBook : the online review of C. elegans biology
  • 2006
This chapter describes the current understanding of the different innate immune responses of C. elegans that follow infection and focuses on the main signalling pathways that have been identified and highlights the inclusion of certain molecular cassettes in both immune and developmental functions.

Molecular mechanisms of resistance to human pathogenic bacteria in Caenorhabditis elegans by MEV-1 mediated oxidative stress.

C. elegans Germline-Deficient Mutants Respond to Pathogen Infection Using Shared and Distinct Mechanisms

It is shown that germline-deficient strains display increased resistance across a broad range of pathogens including Gram positive and Gram negative bacteria, and the fungal pathogen Cryptococcus neoformans, and that the FOXO transcription factor DAF-16, which regulates longevity and immunity in C. elegans, appears to be crucial for maintaining longevity in both wild-type and germline -deficient backgrounds.

Expanding the nematode model system: The molecular basis of inflammation and infection recovery in C. elegans

The wholeorganism Caenorhabditis elegans-pathogen model is used to study the host recovery response from acute Pseudomonas aeruginosa infection and it is found that recovery was dependent on the GATA transcription factor elt-2 and the p38-mitogen-activated protein kinase (MAPK) pmk1.

CHAPTER 6 INNATE IMMUNITY IN C . ELEGANS

The current knowledge of the pathways and effector molecules involved in the nematode immune response, with a particular focus on the antifungal immune response of the C. elegans epidermis is summarized.

Innate immunity in C. elegans.

The current knowledge of the pathways and effector molecules involved in the nematode immune response, with a particular focus on the antifungal immune response of the C. elegans epidermis is summarized.

DAF-16-Dependent Suppression of Immunity During Reproduction in Caenorhabditis elegans

The timing of DAF-16-dependent gene activation in sterile mutants coincides with the onset of embryonic development in wild-type animals, suggesting that signals from developing embryos normally downregulate the immune response.

Insights from the worm: the C. elegans model for innate immunity.

Age influences resistance of Caenorhabditis elegans to killing by pathogenic bacteria.

Caenorhabditis elegans as a model for innate immunity to pathogens

The discovery that the C. elegans worm has inducible defence responses, which to some extent parallel those of other organisms, demonstrates the potential of this model organism for the study of innate immunity.
...

References

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IL-13受体α2降低血吸虫病肉芽肿的炎症反应并延长宿主存活时间[英]/Mentink-Kane MM,Cheever AW，Thompson RW，et al//Proc Natl Acad Sci U S A

入侵病原体与宿主之间呈动态平衡，以维持病原体成功地寄生在宿主体内而不致宿主死亡，这是许多寄生虫感染的一个重要特征。包括曼氏血吸虫在内的许多蠕虫感染中，持续的炎症反应比病原体本身对宿主的危害更大，降低宿主的免疫反应具有重要意义。曼氏血吸虫感染后，宿主活化CD4^＋Th2细胞，分泌IL-4、IL-5和IL-13。最近研究表明IL-13是肝组织纤维化的重要调节因子。

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