Long-Lasting Inhibitory Effects of Fetal Liver Mesenchymal Stem Cells on T-Lymphocyte Proliferation

@inproceedings{Giuliani2011LongLastingIE,
  title={Long-Lasting Inhibitory Effects of Fetal Liver Mesenchymal Stem Cells on T-Lymphocyte Proliferation},
  author={Massimo Giuliani and Maud Fleury and Am{\'e}lia Vernochet and Farah Ketroussi and Denis Clay and Bruno Azzarone and Jean Jacques Lataillade and Antoine Durrbach},
  booktitle={PloS one},
  year={2011}
}
Human bone marrow mesenchymal stem cells (BM-MSC) are multipotent progenitor cells that have transient immunomodulatory properties on Natural Killer (NK) cells, Dendritic Cells (DC), and T cells. This study compared the use of MSC isolated from bone marrow and fetal liver (FL-MSC) to determine which displayed the most efficient immunosuppressive effects on T cell activation. Although both types of MSC exhibit similar phenotype profile, FL-MSC displays a much more extended in vitro life-span and… CONTINUE READING
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and is potentially silenced by DNA methylation during in vitro expansion

  • VM Mikhel’son, IA Gamalei
  • 2011

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