Long-Lasting Hippocampal Synaptic Protein Loss in a Mouse Model of Posttraumatic Stress Disorder

@inproceedings{Herrmann2012LongLastingHS,
  title={Long-Lasting Hippocampal Synaptic Protein Loss in a Mouse Model of Posttraumatic Stress Disorder},
  author={Leonie Herrmann and Irina A. Ionescu and Kathrin Henes and Yulia Golub and Nancy Xin Ru Wang and Dominik R. Buell and Florian Holsboer and Carsten T. Wotjak and Ulrike S. Schmidt},
  booktitle={PloS one},
  year={2012}
}
Despite intensive research efforts, the molecular pathogenesis of posttraumatic stress disorder (PTSD) and especially of the hippocampal volume loss found in the majority of patients suffering from this anxiety disease still remains elusive. We demonstrated before that trauma-induced hippocampal shrinkage can also be observed in mice exhibiting a PTSD-like syndrome. Aiming to decipher the molecular correlates of these trans-species posttraumatic hippocampal alterations, we compared the… CONTINUE READING
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