Long-Lasting Cognitive Deficits Resulting from Adolescent Nicotine Exposure in Rats

@article{Counotte2009LongLastingCD,
  title={Long-Lasting Cognitive Deficits Resulting from Adolescent Nicotine Exposure in Rats},
  author={Danielle S. Counotte and Sabine Spijker and Linda H Van de Burgwal and François Hogenboom and Anton N M Schoffelmeer and Taco J. de Vries and August B. Smit and Tommy Pattij},
  journal={Neuropsychopharmacology},
  year={2009},
  volume={34},
  pages={299-306}
}
Adolescence is a developmental period, during which the brain and particularly medial prefrontal cortical (mPFC) regions thereof have not fully matured. Because epidemiological data have suggested that adolescent nicotine use may result in disturbances in cognitive function in adulthood, we investigated the long-term effects of adolescent nicotine exposure in rats. Male Wistar rats were exposed to either nicotine (three times daily, 0.4 mg/kg s.c.) or saline for 10 days during (postnatal day… CONTINUE READING