Long-Lasting, Antinociceptive Effects of pH-Sensitive Niosomes Loaded with Ibuprofen in Acute and Chronic Models of Pain

@inproceedings{Marzoli2019LongLastingAE,
  title={Long-Lasting, Antinociceptive Effects of pH-Sensitive Niosomes Loaded with Ibuprofen in Acute and Chronic Models of Pain},
  author={Francesca Marzoli and Carlotta Marianecci and Federica Rinaldi and Daniele Passeri and Marco Rossi and Paola Minosi and Maria Carafa and Stefano Pieretti},
  booktitle={Pharmaceutics},
  year={2019}
}
Ibuprofen is one of the non-steroidal anti-inflammatory drugs (NSAIDs) widely used to treat pain conditions. NSAIDs encounter several obstacles to passing across biological membranes. To overcome these constraints, we decided to study the effects of a new pH-sensitive formulation of niosomes containing Polysorbate 20 derivatized by Glycine and loaded with ibuprofen (NioIbu) in several animal models of pain in mice. We performed two tests commonly used to study acute antinociceptive activity… CONTINUE READING
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