Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury

  title={Long-Distance Growth and Connectivity of Neural Stem Cells after Severe Spinal Cord Injury},
  author={Paul Lu and Yaozhi Wang and Lori Graham and Karla McHale and Mingyong Gao and Di Wu and John Brock and Armin Blesch and Ephron S. Rosenzweig and Leif A Havton and Binhai Zheng and James M Conner and Martin Marsala and Mark H Tuszynski},
Neural stem cells (NSCs) expressing GFP were embedded into fibrin matrices containing growth factor cocktails and grafted to sites of severe spinal cord injury. Grafted cells differentiated into multiple cellular phenotypes, including neurons, which extended large numbers of axons over remarkable distances. Extending axons formed abundant synapses with host cells. Axonal growth was partially dependent on mammalian target of rapamycin (mTOR), but not Nogo signaling. Grafted neurons supported… CONTINUE READING
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