Long‐term weight loss effects on all cause mortality in overweight/obese populations

@article{Poobalan2007LongtermWL,
  title={Long‐term weight loss effects on all cause mortality in overweight/obese populations},
  author={Amudha S Poobalan and Lorna Aucott and W. Cairns S. Smith and Alison Avenell and Ronald Jung and John Broom},
  journal={Obesity Reviews},
  year={2007},
  volume={8}
}
This systematic review assesses the long‐term effectiveness of weight loss on all cause mortality in overweight/obese people. Medline, Embase and Cinahl were searched (1966–2005). Cohort studies and trials on participants with body mass index ≥25 kg m−2, with weight change and mortality with ≥2‐year follow‐up, were included finally identifying 11 papers based on eight studies. There may be gender differences in the benefits for all cause mortality. The impact of weight loss in men on mortality… Expand

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ConditionsObese, Type2 Diabetes, Type 2 Diabetes Mellitus
InterventionBehavioral, Procedure
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TLDR
The available evidence does not support solely advising overweight or obese individuals who are otherwise healthy to lose weight as a means of prolonging life, and well-designed intervention studies are needed to disentangle the influence of physical activity, diet strategy and body composition. Expand
Influences of weight loss on long-term diabetes outcomes
  • L. Aucott
  • Medicine
  • Proceedings of the Nutrition Society
  • 2008
TLDR
Weight loss is beneficial for long-term diabetes outcomes for overweight, obese and morbidly-obese participants, and those participants with T2DM often have reduced clinical symptoms and mortality risk. Expand
Weight loss and mortality: a gender-specific analysis of the Tromsø study.
TLDR
In this population-based cohort study in northern Norway of adults, weight loss was associated with excess mortality in men in all subgroups of weight-loss attempts, daily smoking, and overweight. Expand
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TLDR
In obese adults, intentional weight loss may be associated with approximately a 15% reduction in all-cause mortality. Expand
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TLDR
A comprehensive evaluation of recent weight‐cycling evidence is provided, looks to understand design differences between studies and study outcomes, assesses the need for further research on particular health outcomes, and proposes alternative methodologies that will bridge the needs and capabilities of research. Expand
Weight Change and All-Cause Mortality in Older Adults: A Meta-Analysis
TLDR
Weight change is associated with higher mortality risk among community-dwelling adults 60 years and older and none of the study characteristics had statistically significant effects on the pooled RR, except for study quality on weight loss. Expand
Observational Evidence for Unintentional Weight Loss in All-Cause Mortality and Major Cardiovascular Events: A Systematic Review and Meta-Analysis
TLDR
No protective effect of being overweight or obese for unintentional weight loss and MACE is found, and the intentionality of weight loss in all-cause deaths and major cardiovascular events in prospective cohorts is unclear. Expand
Weight change in older adults and mortality: the Multiethnic Cohort Study
TLDR
The findings confirm the association between weight change and a higher mortality in a healthy, multiethnic population, with higher risks for weight loss than weight gain. Expand
Participation in a Structured Weight Loss Program and All-Cause Mortality and Cardiovascular Morbidity in Obese Patients With Chronic Kidney Disease.
TLDR
Participation in a structured weight loss program may be associated with improved outcomes in obese patients with chronic kidney disease. Expand
Long term maintenance of weight loss with non-surgical interventions in obese adults: systematic review and meta-analyses of randomised controlled trials
TLDR
Behavioural interventions that deal with both diet and physical activity show small but significant benefits on weight loss maintenance. Expand
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References

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Effects of weight loss in overweight/obese individuals and long‐term lipid outcomes – a systematic review
  • A. Poobalan, L. Aucott, +4 authors A. Grant
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  • Obesity reviews : an official journal of the International Association for the Study of Obesity
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TLDR
Weight loss has long‐term beneficial effects especially on LDL and cholesterol, and weight loss in obese patients should be encouraged and sustained. Expand
Effects of Weight Loss in Overweight/Obese Individuals and Long-Term Hypertension Outcomes: A Systematic Review
TLDR
The findings, based on studies with follow-up of ≥2 years, demonstrate blood pressure decreases less than this after weight loss, and initial blood pressure, the length of follow- up, medication changes, and physiological restrictions may contribute to this reduced effect in the long-term studies. Expand
Weight loss in obese diabetic and non‐diabetic individuals and long‐term diabetes outcomes – a systematic review
TLDR
Based on one large study, intentional weight loss in obese patients appears to have a beneficial effect on mortality risk for those with type 2 diabetes, and further studies are needed to endorse this. Expand
Intentional Weight Loss and Death in Overweight and Obese U.S. Adults 35 Years of Age and Older
TLDR
The association of weight change and intention to lose weight with all-cause mortality among overweight and obese U.S. adults is estimated and it is found that people who were trying to losing weight had decreased mortality whether they lost weight or not. Expand
Weight loss causes increased mortality: pros
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TLDR
Recommendations to healthy overweight and obese subjects to lose weight must be based on an explicit weighing of the short‐term well‐documented benefits of weight loss, including improvement of quality of life, against the possible risk of an increased mortality in the long term. Expand
Intention to Lose Weight, Weight Changes, and 18-y Mortality in Overweight Individuals without Co-Morbidities
TLDR
Deliberate weight loss in overweight individuals without known co-morbidities may be hazardous in the long term, and the health effects of weight loss are complex, possibly composed of oppositely acting processes. Expand
Prospective study of intentional weight loss and mortality in overweight white men aged 40-64 years.
TLDR
It is suggested that intentional weight loss may reduce the risk of dying from diabetes, but not from CVD, and well-designed observational studies, as well as randomized controlled trials, are needed to determine whether intentional weight lost reduces CVD mortality. Expand
Intentional weight loss: patterns in the general population and its association with morbidity and mortality.
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  • Medicine
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TLDR
Preliminary evidence suggests that modest intentional weight loss is associated with increased longevity in individuals with co-morbidities. Expand
Prospective study of intentional weight loss and mortality in never-smoking overweight US white women aged 40-64 years.
TLDR
The association between intentional weight loss and longevity in middle-aged overweight women appears to depend on their health status, whereas among women with no preexisting illness, the association is equivocal. Expand
Intentional weight loss and mortality among overweight individuals with diabetes.
TLDR
Intentional weight loss was associated with substantial reductions in mortality in this observational study of overweight individuals with diabetes. Expand
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