Long‐term treatment with lansoprazole for patients with Zollinger–Ellison syndrome

@article{Hirschowitz1996LongtermTW,
  title={Long‐term treatment with lansoprazole for patients with Zollinger–Ellison syndrome},
  author={Basil I. Hirschowitz and Jean Mohnen and S. Shaw},
  journal={Alimentary Pharmacology \& Therapeutics},
  year={1996},
  volume={10}
}
Background: Normalization of gastric secretion and cure of associated upper gastrointestinal lesions by resection of gastrinoma is possible in ≈20% of patients with Zollinger–Ellison syndrome, leaving ≈80% dependent on medical treatment with proton pump inhibitors for acid suppression. 
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Helicobacter pylori infection may increase or decrease acid secretion and may augment proton pump inhibitor efficacy in Zollinger–Ellison syndrome (ZE) specifically.
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Treatment with esomeprazole relieved the diarrhea, nausea and vomiting associated with ZES when prescribed at 40 mg twice daily and should be studied further to determine its efficacy and optimal dosing for this difficult-to-treat patient population.
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The treatment of elderly Zollinger-Ellison syndrome patients, similarly to all elderly oncological patients, should be based on the use of comprehensive geriatric assessment, to decide whether the patient can tolerate surgery and/or the stress of antineoplastic therapy, and whether the only possible choice is palliative relief of symptoms.
Insights into Effects/Risks of Chronic Hypergastrinemia and Lifelong PPI Treatment in Man Based on Studies of Patients with Zollinger–Ellison Syndrome
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The insights from studies on ZES into these controversial issues with pertinence to chronic PPI use in non-ZES patients is reviewed, primarily concentrating on data from the prospective long-term studies of ZES patients at NIH.
Evaluation of new diagnostic and treatment strategies in the management of the Zollinger-Ellison syndrome
TLDR
A database of 40 ZES patients treated at Groote Schuur Hospital over two decades is analyzed to investigate a possible correlation between biological tissue marker expression and tumour behaviour and assess the efficacy and safety of a new proton pump inhibitor (pantoprazole) in controlling acid hypersecretion.
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References

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Use of omeprazole in Zollinger‐Ellison syndrome: a prospective nine‐year study of efficacy and safety
TLDR
It is concluded that omeprazole effectively and safely controls gastric acid hypersecretion in all patients with Zollinger‐Ellison syndrome for up to nine years without evidence by tachyphylaxis.
Treatment of patients with Zollinger-Ellison syndrome.
TLDR
It is indicated that lansoprazole is an efficacious, well-tolerated antisecretory agent in patients with Zollinger-Ellison syndrome.
[Dose-response effect of lansoprazole in patients with Zollinger-Ellison syndrome].
TLDR
Data proved that lansoprazole is efficient for treating gastric acid hypersecretion in patients suffering from ZES, with a rapid relief of clinical symptoms.
Prospective study of the need for long‐term antisecretory therapy in patients with Zollinger—Ellison syndrome following successful curative gastrinoma resection
TLDR
It is concluded that following successful curative gastrinoma resection, 40% of patients still require antisecretory therapy and that both symptom evaluation as well as upper endoscopy should be used to guide attempted drug withdrawal.
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TLDR
Treatment of the hypersecretory problems of the Zollinger-Ellison syndrome by total gastrectomy is safe and dependable, and results compare well with those of long-term medical management, whose success is dependent upon serial favorable responses to a lifetime of repeated challenges.
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