Long‐term prognosis in addiction on sedative and hypnotic drugs analyzed with the Cox regression model

@article{Allgulander1987LongtermPI,
  title={Long‐term prognosis in addiction on sedative and hypnotic drugs analyzed with the Cox regression model},
  author={Christer Allgulander and Lennart Ljungberg and Lauren D. Fisher},
  journal={Acta Psychiatrica Scandinavica},
  year={1987},
  volume={75}
}
ABSTRACT— The prognosis of 221 patients first admitted in 1941–1954 for dependence on sedative‐hypnotic drugs was determined in a record‐linkage and interview study concluded in 1984. Different outcomes were related to admission characteristics by means of the Cox proportional hazards regression model. An excess of unnatural deaths was noted; suicides in 11% of the men and 23% of the women. Of those with primary sedative‐hypnotic dependence, 46% continued to abuse drugs till death or follow‐up… 

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Receiving hypnotic prescriptions was associated with greater than threefold increased hazards of death even when prescribed <18 pills/year, and this association held in separate analyses for several commonly used hypnotics and for newer shorteracting drugs.

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