Long‐term follow‐up of pediatric patients receiving total body irradiation before hematopoietic stem cell transplantation and post‐transplant survival of >2 years

@article{Knkele2013LongtermFO,
  title={Long‐term follow‐up of pediatric patients receiving total body irradiation before hematopoietic stem cell transplantation and post‐transplant survival of >2 years},
  author={Annette K{\"u}nkele and Marianne Engelhard and Berthold P. Hauffa and Uwe Mellies and Carsten Muentjes and Claudia H{\"u}er and Angelika Eggert and Johannes H. Schulte and Bernhard Kremens},
  journal={Pediatric Blood \& Cancer},
  year={2013},
  volume={60}
}
Total body irradiation (TBI) treatment eradicates malignant cells and suppresses the immune system before hematopoietic stem cell transplantation (HSCT). The radiation dose is limited by its toxicity to healthy organs. Many reports describe long‐term sequelae from TBI in adults, but comparable data for pediatric patients are scarce. 
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Long‐term brain status and cognitive impairment in children treated for high‐risk acute lymphoblastic leukemia with and without allogeneic hematopoietic stem cell transplantation: A single‐center study
TLDR
Assessment of long‐term consequences of central nervous system (CNS) prophylaxis in patients with high‐risk ALL treated according to ALL IC‐BFM 2002 finds observed abnormalities in patients who underwent allogeneic hematopoietic stem cell transplantation (allo‐HSCT) compared with control group.
Organ sparing total marrow irradiation compared to total body irradiation prior to allogeneic stem cell transplantation
TLDR
Despite small cohorts, some significant differences were found; TMI as part of the myeloablative conditioning yields a high 1-year GRFS, fast and robust engraftment, and low occurrence of acute toxicity.
The importance of long-term follow-up in pediatric hematopoietic stem cell transplantation
TLDR
Most outcome studies of transplant focus on early outcomes, in the first few years after transplant, namely relapse incidence and non-relapse mortality.
Long-Term Side Effects of Hematopoietic Stem Cell Transplantation in Children: A Single Center Experience
TLDR
Long-term side effect risk was higher in patients underwent allo-HSCT in older age and chronic graft versus host disease (GVHD) rate was increased with MUD transplantation and acute liver GVHD, and osteoporosis frequency was positively correlated with follow-up time.
Comparison of Total Body Irradiation–based Versus Chemotherapy-based Conditionings for Early Complications of Allogeneic Hematopoietic Stem Cell Transplantation in Children With ALL
TLDR
The findings support chemotherapy-based regimens with early neutrophil engraftment, less ES andCMV reactivation compared with TBI, and increased incidence of ES and CMV reactivated should be considered in TBI-based Regimens.
Total Body Irradiation in Haematopoietic Stem Cell Transplantation for Paediatric Acute Lymphoblastic Leukaemia: Review of the Literature and Future Directions
TLDR
Standardisation and comprehensive reporting of conventional TBI techniques as well as cooperation between radiotherapy centres may help to increase the ratio between treatment outcomes and toxicity, and future studies must determine potential added benefit of innovative conformal techniques to ultimately improve quality of life for paediatric ALL patients receiving TBI-conditioned HSCT.
Long-term Effects of Myeloablative Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Patients with Acute Lymphoblastic Leukemia
TLDR
Patients after HSCT in childhood have a high risk for developing a wide range of late sequelae and may benefit from regular screening and early intervention and an organ-based overview that covers main clinical patterns, incidence, and risk factors enhanced by current references and screening guidelines.
Haploidentical peripheral blood stem cell transplantation with posttransplant cyclophosphamide in children and adolescents with hematological malignancies
Haploidentical hematopoietic stem cell transplantation (haplo‐HSCT) using posttransplant cyclophosphamide (Cy) for graft versus host disease (GVHD) prophylaxis has emerged as an alternative…
Pulmonary Toxicity After Total Body Irradiation – Critical Review of the Literature and Recommendations for Toxicity Reporting
TLDR
A critical review of the literature describing pulmonary outcomes after TBI is performed to recommend routine adoption of the diagnostic workup and the definition of IPS proposed by the American Thoracic Society.
Adverse health events and late mortality after pediatric allogeneic hematopoietic SCT—two decades of longitudinal follow-up
TLDR
The occurrence of AEs after pediatric allo-HSCT is high and likely to increase during extended follow-up, particularly in patients who have received TBI, and HRTs were more frequent after TBI.
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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