Long‐term follow‐up of melatonin treatment in children with ADHD and chronic sleep onset insomnia

@article{Hoebert2009LongtermFO,
  title={Long‐term follow‐up of melatonin treatment in children with ADHD and chronic sleep onset insomnia},
  author={Michel Hoebert and Kristiaan B van der Heijden and Ingeborg M van Geijlswijk and Marcel G. Smits},
  journal={Journal of Pineal Research},
  year={2009},
  volume={47}
}
Abstract:  We conducted this study to assess long‐term melatonin treatment course, effectiveness and safety in children with attention‐deficit/hyperactivity disorder (ADHD) and chronic sleep onset insomnia (CSOI). This was conducted by means of a structured questionnaire for the parents. The subjects of this study consisted of participants who previously participated in a randomised clinical trial on melatonin efficacy. The response rate was 93% (94/101). The mean time to follow up was 3.7 yr… 
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Melatonin is effective in advancing sleep-wake rhythm and endogenous melatonin rhythm in delayed sleep phase disorder.
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TLDR
Prolonged-release melatonin remains a safe, effective therapy for the long-term treatment of sleep disorders in children with neurodevelopmental disorders.
Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview
TLDR
Evidence has been provided that melatonin is an efficacious and safe chronobiotic drug for the treatment of DSPD in children, provided that it is administered at the correct time (3–5 h before endogenous melatonin starts to rise in dim light (DLMO)), and in the correct (minimal effective) dose.
Long-Term Melatonin Therapy for Adolescents and Young Adults with Chronic Sleep Onset Insomnia and Late Melatonin Onset: Evaluation of Sleep Quality, Chronotype, and Lifestyle Factors Compared to Age-Related Randomly Selected Population Cohorts
TLDR
It is shown that ten years after initiation of treatment with melatonin for CSOI, approximately 75% of the patients will have normal sleep quality without medication and appears to be safe.
Pharmacologic Treatments for Sleep Disorders in Children: A Systematic Review
TLDR
Improvement in sleep was greatest in children with autism or other neurodevelopmental disorders, and smaller in adolescents and children with chronic delayed sleep onset, and other drugs and outcomes are inadequately studied.
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