Long‐term efficacy and safety of a permeation‐enhanced testosterone transdermal system in hypogonadal men
@article{Arver1997LongtermEA, title={Long‐term efficacy and safety of a permeation‐enhanced testosterone transdermal system in hypogonadal men}, author={Stefan Arver and Adrian S. Dobs and A. Wayne Meikle and Kim E. Caramelli and Lakshminaryan Rajaram and Steven W. Sanders and Norman A. Mazer}, journal={Clinical Endocrinology}, year={1997}, volume={47} }
An important aim in treating male hypogonadism is restoration of physiological concentrations of testosterone and its metabolites. We have assessed hormone levels, pharmacokinetics and clinical response, including safety, of a permeation‐enhanced testosterone transdermal system (TTD) in the treatment of hypogonadal men for a 12‐month period.
136 Citations
Efficacy and safety of the 2% formulation of testosterone topical solution applied to the axillae in androgen‐deficient men
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- 2011
Testosterone replacement therapy in hypogonadal men relieves symptoms and restores serum testosterone levels to the physiological range and the safety, pharmacokinetics, and efficacy of the 2% formulation of testosterone topical solution applied daily to the axillae are assessed.
A novel testosterone gel formulation normalizes androgen levels in hypogonadal men, with improvements in body composition and sexual function
- Medicine, BiologyBJU international
- 2003
To compare the safety and efficacy of two doses of a new testosterone gel formulation to a permeation‐enhanced testosterone patch for treating men with confirmed low serum testosterone levels, and associated signs and symptoms of hypogonadism.
Transdermal testosterone gel: pharmacokinetics, efficacy of dosing and application site in hypogonadal men
- Biology, MedicineBJU international
- 2004
The authors from the USA evaluated the pharmacokinetics and the efficacy of dosing and application sites of another such transdermal gel.
Randomized placebo‐controlled trial of testosterone replacement in men with mild Leydig cell insufficiency following cytotoxic chemotherapy
- Medicine, BiologyClinical endocrinology
- 2001
OBJECTIVE Testosterone deficiency is associated with significant morbidity, and androgen replacement in overt hypogonadism is clearly beneficial. However, there are few data concerning the response…
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- Medicine, BiologyClinical endocrinology
- 1999
To assess the quality of this new form of T substitution, hypogonadal men treated by transdermal T up to 10 years were followed and scrotal T patches were followed.
Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system.
- Medicine, BiologyThe Journal of urology
- 1996
Alterations in hepatic lipase and lipoprotein subfractions with transdermal testosterone replacement therapy
- Biology, MedicineClinical endocrinology
- 1999
Evaluated the effects of testosterone replacement therapy given transdermally via a permeation‐enhanced system on plasma lipolytic enzymes (hepatic and lipoprotein lipase), LDL and HDL subfraction concentrations.
New Modalities of Transdermal Testosterone Replacement
- Medicine, BiologyTreatments in endocrinology
- 2003
Transdermal testosterone replacement improves bone mass and lean body mass, decreases fat mass, and improves mood and sexual function, and there are no harmful effects on the prostate and lipids.
Prostate‐specific antigen (PSA) concentrations in hypogonadal men during 6 years of transdermal testosterone treatment
- Medicine, BiologyBJU international
- 2013
It is shown that, over the long‐term, Testopatch was associated with no relevant changes in PSA concentration and PSA velocity, or any significant prostate risks (there were no cases of prostate cancer).
Drug Insight: testosterone preparations
- Biology, MedicineNature Clinical Practice Urology
- 2006
Transdermal patches, gels, mucoadhesive sustained-release buccal tablets and long-acting testosterone esters are designed to provide testosterone levels that approximate normal physiologic levels, to improve patient acceptability, and to further increase the number of treatment options available.
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