Long‐term Effects of Maternal Magnesium Restriction on Adiposity and Insulin Resistance in Rat Pups

@article{Venu2008LongtermEO,
  title={Long‐term Effects of Maternal Magnesium Restriction on Adiposity and Insulin Resistance in Rat Pups},
  author={Lagishetty Venu and Inagadapa J.N. Padmavathi and Yedla Durga Kishore and Nandiwada V. Bhanu and Kalashikam Rajender Rao and Pothaganti B. Sainath and Manisha Ganeshan and Manchala Raghunath},
  journal={Obesity},
  year={2008},
  volume={16}
}
Objective: We investigated the long‐term effects of maternal/postnatal magnesium (Mg) restriction on adiposity, glucose tolerance, and insulin secretion in the offspring and the probable biochemical mechanisms associated with them. 
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Magnesium-deficient high-fat diet: effects on adiposity, lipid profile and insulin sensitivity in growing rats.
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Protein phosphorylation in the insulin-signaling pathway was significantly reduced in the high-fat groups compared with the control groups, demonstrating that the intake of fat-rich diets increased insulin resistance, a syndrome that was aggravated by magnesium deficiency.
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